Protein Details: Aquaporin-2

Protein ID

ICDB_Pro_0518

Protein Name

Aquaporin-2

Gene Name

AQP2

Organism

Homo sapiens (Human)

Length

271 amino acids

AlphaFoldDB

AF-P41181-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis.

Sequence

MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA

PDB Structures

4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Diabetes Insipidus;Nephrogenic;Autosomal and Nephrogenic Diabetes Insipidus

Location

Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718).

DOI ID

10.1126/science.8140421; 10.1016/s0021-9258(17)31537-5; 10.1172/jci117079; 10.1093/hmg/11.7.779; 10.1101/gr.2596504; 10.1074/jbc.m207525200; 10.1021/jacs.0c00706; 10.1186/s12943-022-01654-1; 10.1073/pnas.1321406111; 10.1007/s004390050264; 10.1093/hmg/6.11.1865; 10.1681/asn.v82242; 10.1681/asn.v8121855; 10.2169/internalmedicine.37.215; 10.1172/jci2605; 10.1210/jcem.83.9.5074; 10.1097/01.asn.0000027355.41663.14; 10.1210/jcem.87.6.8617; 10.1093/hmg/ddh339; 10.1681/asn.2005010104; 10.3346/jkms.2005.20.6.1076; 10.1097/01.gim.0000223554.46981.7a; 10.1002/humu.21082; 10.1002/humu.21068; 10.3892/br.2014.283

RefSeq

NP_000477.1